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KMID : 0380519980020010017
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Korean Journal of Veterinary Pathology
1998 Volume.2 No. 1 p.17 ~ p.23
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Expression of c-Jun in pancreatic islet a-cells of nonobese diabetic(NOD) mice
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Park Sang-Joon
Lee Cha-Soo
Jeong Kyu-Shik
Lee Sae-Bom
Choi Yang-Kyu
Lee Chul-Ho
Hyun Byung-Hwa
Lee Keun-Joa
Ryu Si-Yun
Cho Sung-Whan
Song Jae-Chan
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Abstract
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This is the first report of c-Jun protein expression and mRNA in a pancreatic islet in a nonobese diabetic(NOD) state mice. In this experiment NOD mice with insulin-dependent diabetes mellitus type I at age 16 weeks(n=7) just before death(n=4) were used. The control group consist of prediabetic NOD(8 weeks n=7) and ICR(8 weeks n=7 and 16 weeks n=7) mice. c-Jun positive cells in the pancreatic islet of NOD mice were localized in the same positions as a-glucagon producing cells. immunoreactivity was negative in the prediabetic NOD(8 weeks) and ICR(8 weeks and 16 weeks) mice. The number of c-Jun positive cells in mice with severe diabetic state just before death were significantly decreased when compared to NOD(16 weeks) mice. Expression of c-Jun in mRNA level was assessed by RT-PCR method. The levels of mRNA in NOD(16 weeks) mice group were elevated in total pancreatic tissues. The present results suggest that the induction of proto-oncogene protein may be of significance in assessing cell specific injury and may play a functional role between pancretic islet α-cells and β-cells in the diabetic state.
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KEYWORD
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c-Jun, nonobese diabetic mice(NOD), pancreatic islet α-cell
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